publication . Other literature type . 2021

A Class of Simple Biomolecular Antithetic Proportional-Integral-Derivative Controllers

Maurice Filo; Mustafa Khammash;
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  • Published: 22 Mar 2021
  • Publisher: Cold Spring Harbor Laboratory
Abstract
AbstractProportional-Integral-Derivative (PID) feedback controllers have been the most widely used controllers in the industry for almost a century. This is mainly due to their simplicity and intuitive operation. Recently, motivated by their success in various engineering disciplines, PID controllers found their way into molecular biology. In this paper, we consider the mathematical realization of (nonlinear) PID controllers via biomolecular interactions in both the deterministic and stochastic settings. We propose several simple biomolecular PID control architectures that take into consideration the biological implementation aspect. We verify the underlying PID...
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