publication . Article . Other literature type . 2021

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

Mariana Galvão Ferrarini; Avantika Lal; Rita Rebollo; Andreas J. Gruber; Andrea Guarracino; Itziar Martinez Gonzalez; Taylor Floyd; Daniel Siqueira de Oliveira; Justin Shanklin; Ethan Beausoleil; ...
Open Access English
  • Published: 01 Dec 2021 Journal: Communications Biology, volume 4 (eissn: 2399-3642, Copyright policy)
  • Publisher: Nature Publishing Group UK
  • Country: France
Abstract
Ferrarini & Lal et al. developed a novel bioinformatic pipeline to explore how SARS-CoV-2 interacts with human respiratory cells using public available host gene expression and viral genome sequence data. Several human genes and proteins were predicted to play a role in the viral life cycle and the host response to SARS-CoV-2 infection.
Subjects
Medical Subject Headings: fungi
free text keywords: Article, SARS-CoV-2, RNA, Computational biology and bioinformatics, Transcriptomics, Viral infection, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Biology (General), QH301-705.5, Betacoronavirus, biology.organism_classification, biology, Transposable element, Genetics, DNA sequencing, Genome, RNA, Viral life cycle, Polymerase, biology.protein, Disease
Communities
COVID-19
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