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Publication . Preprint . Other literature type . 2020

Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

Stuart P. Weisberg; Thomas J. Connors; Yun Zhu; Matthew R. Baldwin; Wen-Hsuan W. Lin; Sandeep N. Wontakal; Peter A. Szabo; +21 Authors
Open Access
English
Published: 30 Dec 2020
Publisher: HAL CCSD
Country: France
Abstract
ABSTRACTClinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki’s disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while the COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to both COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.
Subjects by Vocabulary

Microsoft Academic Graph classification: Coronavirus medicine.disease_cause medicine Immunology Immune system Respiratory disease medicine.disease Antibody biology.protein biology Serology ARDS business.industry business Disease Coronavirus disease 2019 (COVID-19)

Subjects

[SDV.IMM]Life Sciences [q-bio]/Immunology, Article

Funded by
NIH| Development of Localized T Cell Immunity in Pediatric Respiratory Tract Infection
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K23AI141686-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Development of therapeutic fusion inhibitor peptides for Measles encephalitis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01NS105699-01A1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| Bioinformatics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P01AI106697-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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Preprint . 2020
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