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Bladder cancer

Authors: Daniel A, Barocas; Peter E, Clark;
Abstract

To review the diagnosis and management of bladder cancer with an emphasis on studies and developments over the past year.Cystoscopy remains the mainstay in the detection and surveillance of bladder cancer, though fluorescent light may enhance detection. Efforts continue in the development of urinary bladder cancer markers. Superficial bladder cancer is still managed with transurethral resection and perioperative instillation of chemotherapy for most patients. The data support the use of intravesical bacillus Calmette-Guerin (including a maintenance regimen) for those at high risk for progression. The gold standard for management of muscle invasive disease is radical cystectomy. Research on the use of laparoscopy, the effect on patients' health-related quality of life, and the potential role for bladder preservation strategies is ongoing. The value of neoadjuvant versus adjuvant chemotherapy around the time of cystectomy is still debated. Methotrexate, vinblastine, doxorubicin, and cisplatin and gemcitabine and cisplatin remain the most commonly used chemotherapy regimens, but work is ongoing to develop new regimens, especially in patients who cannot take cisplatin.We are encouraged by the progress in bladder cancer diagnosis and management, but considerably more work needs to be done to improve on the lives of our patients with this disease.

Related Organizations
Keywords

Urinary Bladder Neoplasms, Chemotherapy, Adjuvant, Biomarkers, Tumor, Disease Progression, Humans, Lymph Node Excision, Antineoplastic Agents, Cystectomy, Prognosis

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
54
Top 10%
Top 10%
Top 10%
Related to Research communities
Cancer Research
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