Fractures not related to birth trauma were diagnosed in 1.2% of preterm infants between the 24th and the 160th day of life. The clinical and radiologic findings as well as the follow-up on 12 preterm infants with one or more fractures were reviewed. Fractures occurred either in the ribs or long bones or both. Their clinical history, the radiographic appearance, and laboratory data suggest that most of the infants may have suffered from bone loss associated with low intake of calcium and phosphorus. Improving the metabolic status and removing the risk factors prevented further fractures and led to good healing.