Globally, gastroesophageal reflux disease (GERD) remains a common and important clinical disorder. This review summarizes the major advances in the understanding and treatment of GERD that have been made in the past 12 months. Epidemiologic studies have yielded additional data on the clinical presentation and natural history of GERD in the East. Further insights have been presented on the pathogenesis of GERD, including the immunoregulatory environment of GERD, the neurophysiology of transient lower esophageal sphincter relaxation (TLESR), the mechanics of the esophagogastric junction as well as the influence of Helicobacter pylori. Diagnostically, a new acid exposure sensor may be a helpful cost-effective tool. Developments have been made in pharmacotherapy for TLESR. There is ongoing interest in endoscopic therapy and further developments have been made in laparoscopic fundoplication. The cost-effectiveness of several management strategies has been evaluated, aiming to reduce the cost impact of GERD on the health care system.