publication . Article . 2020

Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study

Jennifer C E Lane; James Weaver; Kristin Kostka; Talita Duarte-Salles; Maria Tereza Fernandes Abrahão; Heba Alghoul; Osaid Alser; Thamir M. Alshammari; Carlos Areia; Patricia Biedermann; ...
Open Access
  • Published: 25 Dec 2020 Journal: Rheumatology (issn: 1462-0324, eissn: 1462-0332, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract Objectives Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA. Methods We performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients ≥18 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outco...
Persistent Identifiers
free text keywords: Pharmacology (medical), Rheumatology, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, OHDSI-COVID-19 consortium, HCQ, depression, epidemiology, RA, psychosis, safety, Arthritis & Rheumatology, Clinical Sciences, Immunology, Public Health and Health Services, Hydroxychloroquine, Rheumatoid Arthritis, COVID-19, Original Article, AcademicSubjects/MED00360, HCQ, safety, epidemiology, RA, psychosis, depression, Suicide prevention, Poison control, Internal medicine, medicine.medical_specialty, medicine, Suicidal ideation, medicine.symptom, Hazard ratio, business.industry, business, Propensity score matching, Proportional hazards model, Cohort study, Confounding
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European Health Data and Evidence Network
  • Funder: European Commission (EC)
  • Project Code: 806968
  • Funding stream: H2020 | IMI2-RIA
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