Costa Rica is one of the most biotically diverse countries on earth, with 4% of known terrestrial plant and animal species in only 0.04% of the world’s land surface. The country’s mammal fauna is equally diverse, with more than 207 species (4.8% of the world’s 4629 species) in an area of 51,022 km2. The majority of the world’s mammal species and Monteverde’s fauna are small (< 0.5 kg), nocturnal, and secretive. We know considerably less about most neotropical mammals and other vertebrates than we do about birds, which are more easily observed and communicate with sounds audible to humans. Although certain species of mammals have been studied in Costa Rica (Janzen 1983a, Timm 1994, Vaughan and Rodríguez 1994), and Monteverde is one of the best-known regions of the country biologically, there has been little work on the ecology, distribution, abundance, altitudinal zonation, systematic relationships, and biogeography of most mammals. Deforestation and other human disturbances have had a significant impact on the native mammals of the region; knowledge of Monteverde’s mammals is vital to understand how habitat changes affect tropical montane mammals. In this chapter, we provide an overview of the mammal fauna of the Monteverde area. We discuss the biology and abundance of some of the area’s species, document how these are changing, and explore conservation issues. Most of the research on mammals at Monteverde has centered on bats or rodents, the two most diverse groups. Much of our knowledge of other species consists of isolated observations. We augment published reports with unpublished observations made by ourselves and colleagues. We also examined most of the Monteverde mammal specimens in museum collections to verify species identifications and to understand better their systematics, ecology, and distribution. We integrate this information into a list of the mammals that occur in the region, document their occurrence in each life zone, and estimate their overall abundance.