Reliability of the Treponemal Hemagglutination Test for the Serodiagnosis of Syphilis
Copyright policy )Reliability of the Treponemal Hemagglutination Test for the Serodiagnosis of Syphilis
The reliability of the treponemal hemagglutination (TPHA) test for the serodiagnosis of syphilis was evaluated by testing 306 sera with the TPHA and fluorescent treponemal antibody-absorbed (FTA-Abs) tests. Overall agreement between the two tests was obtained with 90.2% of the sera. Fifteen of the discrepant sera were FTA-Abs-positive and TPHA-negative, and fifteen were FTA-Absnegative and TPHA-positive. Careful evaluation of the patients' history and clinical findings indicated a false-positive rate of 8.8% for the TPHA, and a false-negative rate of at least 6.5% for this test. The number of false-positives and false-negatives makes us question the reliability of the TPHA, and it is recommended that the FTA-Abs be retained as the primary treponemal test.
- King’s University United States
- Presbyterian Medical Center Korea (Republic of)
Fluorescent Antibody Technique, Hemagglutination Tests, Immunoglobulin E, Syphilis Serodiagnosis, Arthritis, Rheumatoid, Evaluation Studies as Topic, Antibodies, Antinuclear, Hypergammaglobulinemia, Methods, Humans, False Positive Reactions, Syphilis, Treponema pallidum, False Negative Reactions
Fluorescent Antibody Technique, Hemagglutination Tests, Immunoglobulin E, Syphilis Serodiagnosis, Arthritis, Rheumatoid, Evaluation Studies as Topic, Antibodies, Antinuclear, Hypergammaglobulinemia, Methods, Humans, False Positive Reactions, Syphilis, Treponema pallidum, False Negative Reactions
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