publication . Article . Other literature type . 2011

PCOS, coronary heart disease, stroke and the influence of obesity: A systematic review and meta-analysis

P. C. M. de Groot; Olaf M. Dekkers; Johannes A. Romijn; S. W. M. Dieben; Frans M. Helmerhorst;
Open Access
  • Published: 31 Aug 2011
Abstract
BACKGROUND: Patients with polycystic ovary syndrome (PCOS) are at risk of arterial disease. We examined the risk of (non) fatal coronary heart disease (CHD) or stroke in patients with PCOS and ovulatory women without PCOS, and assessed whether obesity might explain a higher risk of CHD or stroke. METHODS: We performed a systematic review and meta-analysis of controlled observational studies. Four definitions of PCOS were considered: World Health Organization type II anovulation, National Institutes of Health criteria, Rotterdam consensus and Androgen-excess criteria. Obesity was defined as BMI. 30 kg/m(2) and/or waist circumference >88 cm. Study quality was asse...
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Medical Subject Headings: nutritional and metabolic diseasesendocrine system diseases
free text keywords: polycystic ovary syndrome, systematic review, arterial disease, obesity, BMI, Obstetrics and Gynaecology, Reproductive Medicine, Stroke, medicine.disease, medicine, Observational study, Relative risk, Heart disease, Physical therapy, medicine.medical_specialty, Waist, Internal medicine, Confidence interval, Polycystic ovary, Meta-analysis, business.industry, business
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