CTLA-4: From conflict to clinic
Copyright policy ) Bashyam, Hema;
CTLA-4: From conflict to clinic
CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity.
From the Archive, Antigens, CD, B7-1 Antigen, Humans, CTLA-4 Antigen, CD8-Positive T-Lymphocytes, Antigens, Differentiation, Immunosuppressive Agents, Cell Proliferation
From the Archive, Antigens, CD, B7-1 Antigen, Humans, CTLA-4 Antigen, CD8-Positive T-Lymphocytes, Antigens, Differentiation, Immunosuppressive Agents, Cell Proliferation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 17
Top 10%
Average
Average
Green
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