publication . Article . 2009

Mini ReviewHuman Interferons Alpha, Beta and Omega

Bekisz, Joseph; Schmeisser, Hana; Hernandez, Jessica; Goldman, Neil D.; Zoon, Kathryn C.;
Open Access
  • Published: 07 Aug 2009
  • Publisher: Informa UK Limited
Abstract
Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.
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free text keywords: Cell Biology, Clinical Biochemistry, Endocrinology, Genetics, Beta (finance), Biology, Receptor, Gene, Signal transduction, Alpha (ethology), Structure–activity relationship, Peptide sequence, Janus kinase 1, Cell biology
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