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Publication . Article . 2012

Double-functionalized nanopore-embedded gold electrodes for rapid DNA sequencing

Biswarup Pathak; Henrik Löfås; Jariyanee Prasongkit; Anton Grigoriev; Rajeev Ahuja; Ralph H. Scheicher;
Open Access
Published: 09 Jan 2012 Journal: Applied Physics Letters, volume 100, page 23,701 (issn: 0003-6951, eissn: 1077-3118, Copyright policy )
Publisher: AIP Publishing
Abstract

We have studied the effect of double-functionalization on gold electrodes for improving nanopore-based DNA sequencing. The functionalizing molecular probes are, respectively, capable of temporarily forming hydrogen bonds with both the nucleobase part and the phosphate group of the target DNA, thus potentially minimizing the structural fluctuations of a single-stranded DNA molecule passing between the gold electrodes. The results of our first-principles study indicate that the proposed setup yields current signals that differ by at least 1 order of magnitude for the four different nucleic acid bases, thus offering the possibility to electrically distinguish them.

Subjects by Vocabulary

Microsoft Academic Graph classification: DNA sequencing Nucleobase DNA chemistry.chemical_compound chemistry Nucleic acid Molecular probe Nanopore Nanobiotechnology Nanotechnology Molecular biophysics

Subjects

Physics and Astronomy (miscellaneous)

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Applied Physics Letters
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License: cc-by-sa
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