Traditional sensitivity analysis of a chemical reaction system’s periodic trajectory shows how the oscillation depends on the reaction rate constants. We develop sensitivity analysis within the framework of a stoichiometric network analysis, which is a theory that relates the dynamics of complex chemical reaction systems to feedback loops in the reaction network. The combined theory shows how the properties of a chemical oscillation are related to parameters that reflect the topology of the reaction network rather than to the rate constant parameters. The theory is applied to a Brusselator limit cycle as an example.