publication . Article . 2021

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Gordon, A.C.; Mouncey, P.R.; Al-Beidh, F.; Rowan, K.M.; Nichol, A.D.; Arabi, Y.M.; Annane, D.; Beane, A.; van Bentum-Puijk, W.; Berry, L.R.; ...
Open Access English
  • Published: 22 Apr 2021 Journal: New England Journal of Medicine, volume 384, issue 16, pages 1,491-1,502 (issn: 0028-4793, eissn: 1533-4406, Copyright policy)
Abstract
BACKGROUNDThe efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.METHODSWe evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive care unit (ICU), were randomly assigned to receive tocilizumab (8 mg per kilogram of body weight), sarilumab (400 mg), or standard care (control). The primary outcome was respiratory and cardiovascular organ support–free days, on an ordinal scale combining in-hospital death (assigned a value of −1) and days free of organ...
Subjects
free text keywords: General Medicine, /dk/atira/pure/core/keywords/uob_covid19, Covid19, Original Article, [SDV]Life Sciences [q-bio], REMAP-CAP Investigators, 11 Medical and Health Sciences, General & Internal Medicine
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Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| PREPARE
Project
PREPARE
Platform foR European Preparedness Against (Re-)emerging Epidemics
  • Funder: European Commission (EC)
  • Project Code: 602525
  • Funding stream: FP7 | SP1 | HEALTH
,
EC| RECoVER
Project
RECoVER
Rapid European SARS-CoV-2 Emergency research Response
  • Funder: European Commission (EC)
  • Project Code: 101003589
  • Funding stream: H2020 | RIA
Validated by funder
,
EC| CREDITS4HEALTH
Project
CREDITS4HEALTH
Credits-based, people-centric approach for the adoption of healthy life-styles and balanced Mediterranean diet in the frame of social participation and innovation for health promotion.
  • Funder: European Commission (EC)
  • Project Code: 602386
  • Funding stream: FP7 | SP1 | HEALTH
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