publication . Article . 2008

Ketoconazole Binds to the Human Androgen Receptor

C Eil;
Open Access
  • Published: 07 Nov 2008
Abstract
Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. Based on these potent effects on gonadal function in vivo as well as previous work in vitro demonstrating affinity of ketoconazole for receptor proteins for glucocorticoids and 1,25(OH)2 vitamin D3 and for sex steroid binding globulin (SSBG), the binding of ketoconazole to human androgen receptors (AR) in vitro was also examined. Ketoconazole competition with [3H]methyltrienolone (R1881) for androgen binding sites ...
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free text keywords: Biochemistry, medical, Clinical Biochemistry, Endocrinology, Biochemistry, General Medicine, Endocrinology, Diabetes and Metabolism, Androgen, medicine.drug_class, medicine, Miconazole, medicine.drug, Androgen receptor, Metribolone, chemistry.chemical_compound, chemistry, Steroid hormone, medicine.medical_treatment, Androgen binding, Androgen deficiency, medicine.disease, Endocrinology, medicine.medical_specialty, Pharmacology, Biology, Ketoconazole, Internal medicine
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