Maintaining the protective variant surface glycoprotein coat of African trypanosomes
Copyright policy )Maintaining the protective variant surface glycoprotein coat of African trypanosomes
The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during the course of a chronic infection. New data demonstrate a link between VSG synthesis and cell cycle progression, indicating that VSG is monitored during the trypanosome cell cycle.
- Medawar Building for Pathogen Research United Kingdom
- University of Oxford United Kingdom
Gene Expression Regulation, Trypanosoma brucei gambiense, Cell Cycle, Protozoan Proteins, Animals, RNA Interference, Variant Surface Glycoproteins, Trypanosoma
Gene Expression Regulation, Trypanosoma brucei gambiense, Cell Cycle, Protozoan Proteins, Animals, RNA Interference, Variant Surface Glycoproteins, Trypanosoma
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