53BP1: function and mechanisms of focal recruitment
Copyright policy )53BP1: function and mechanisms of focal recruitment
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
- University of Galway Ireland
histone h2ax, DNA Repair, Chromosomal Proteins, Non-Histone, mediator of DNA-damage checkpoint 1 (mdc1), rad9, Models, Biological, ubiquitin ligase, DNA-damage-response, Histones, dot1, Animals, Humans, budding yeast, histone methylation, p53-binding protein 1 (53bp1), double-strand breaks, cellular-response, Intracellular Signaling Peptides and Proteins, genomic instability, DNA-Binding Proteins, checkpoint protein crb2, histone 2ax (h2ax), class-switch recombination, saccharomyces-cerevisiae, Tumor Suppressor p53-Binding Protein 1, DNA Damage
histone h2ax, DNA Repair, Chromosomal Proteins, Non-Histone, mediator of DNA-damage checkpoint 1 (mdc1), rad9, Models, Biological, ubiquitin ligase, DNA-damage-response, Histones, dot1, Animals, Humans, budding yeast, histone methylation, p53-binding protein 1 (53bp1), double-strand breaks, cellular-response, Intracellular Signaling Peptides and Proteins, genomic instability, DNA-Binding Proteins, checkpoint protein crb2, histone 2ax (h2ax), class-switch recombination, saccharomyces-cerevisiae, Tumor Suppressor p53-Binding Protein 1, DNA Damage
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