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Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2021 United Kingdom Publisher:Royal Society of Chemistry (RSC)Journal:Lab on a Chip, volume 21, pages 2,437-2,452 (issn: 1473-0197, eissn: 1473-0189,

Authors: Uvizi, Alena; Goswami, Ruchi; Gandhi, Shanil Durgeshkumar; Augsburg, Martina; Buchholz, Frank; Guck, Jochen; Mansfeld, Jörg; +1 Authors

doi: 10.1039/d0lc01224f , 10.5281/zenodo.6577811 , 10.5281/zenodo.6578354 , 10.5281/zenodo.6577810 , 10.5281/zenodo.6578353

pmid: 33977944

pmc: PMC8204113

handle: 21.11116/0000-000A-07FB-4 , 21.11116/0000-000A-07FD-2

Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation

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Abstract

Progressive Mechanoporation, a novel mechanoporation method that improves the delivery efficiency of molecules into cells of different elasticity via a multistage cell deformation controlled by a PDMS-based microfluidic platform.

Country

United Kingdom

Related Organizations

Technische Universität Dresden, Biotechnology Center
Germany
Max Planck Society
Germany
TU Dresden
Germany
INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL
United Kingdom
University Hospital Carl Gustav Carus
Germany

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Keywords

Cell Membrane Permeability, Cell Membrane, Microfluidics, 610, 612, Cell mechanics, Intracellular delivery, Lab on a chip, Mechanoporation, 540, Stress, Mechanical, Transfection, Elasticity, Chemistry, Gene therapy, Stress, Mechanical

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