Organic semiconductors have emerged in the past two decades as promising materials for many technological applications. Thanks to their unique optoelectronic properties, they represent an ideal system to mimic natural photoreceptor functioning. This similarity has been exploited, on one hand, to realize organic-based devices for image detection, taking advantage of typical features of natural visual systems, such as trichromatic sensing; on the other hand, these materials can be interfaced with biological tissues for cell photo-stimulation, with the main goal of restoring light sensitivity in the case of retinas affected by photoreceptor degeneration.