descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:Royal Society of Chemistry (RSC)Journal:RSC Advances, volume 2, page 3,670 (eissn: 2046-2069,

Authors: Nicole F. Steinmetz; Amy M. Wen; Sourabh Shukla; Ibrahim Yildiz; Irina B. Tsvetkova; M. Hema Masarapu; Bogdan Dragnea;

doi: 10.1039/c2ra01376b

pmid: 28018580

pmc: PMC5180450

Engineering of Brome mosaic virus for biomedical applications

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Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

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