Catalytic metallodrugs targeting HCV IRES RNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2012 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 48, page 3,118 (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )

Authors: Seth, Bradford; J A, Cowan;

doi: 10.1039/c2cc17377h

pmid: 22343977

Catalytic metallodrugs targeting HCV IRES RNA

- Summary
- Subjects
- Metrics

Abstract

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.

Related Organizations

The Ohio State University
United States

Keywords

Kinetics, Binding Sites, Pharmaceutical Preparations, RNA, Ribosomal, RNA, Viral, Replicon, Amino Acid Sequence, Hepacivirus, Antiviral Agents, Catalysis

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	39
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%