publication . Article . Review . 2013

Energy metabolism and fertility—a balance preserved for female health

Roberta Fontana; Adriana Maggi; Sara Della Torre; Valeria Benedusi;
Open Access English
  • Published: 22 Oct 2013
  • Country: Italy
Abstract
In female animals, energy metabolism and fertility are tightly connected, and reciprocally regulated. However, the relative contributions of metabolic and reproductive pathways have changed over the course of evolution. In oviparous animals, metabolic factors take precedence over fertility, enabling egg production to be inhibited in a nutritionally poor environment. By contrast, in placental mammals, the opposite occurs: the need to feed a developing embryo and neonate forces metabolic pathways to adapt to these reproductive needs. This physiological necessity explains why in female mammals alterations of gonadal activity, including age-dependent cessation of ov...
Subjects
free text keywords: Estrogen-receptor-alpha; polycystic-ovary-syndrome; nonalcoholic fatty liver; induced inflammatory response; cardiovascular risk-factors; turner-syndrome; insulin-resistance; gene-expression; food-intake; vitellogenin synthesis, Settore BIO/14 - Farmacologia, Settore BIO/09 - Fisiologia, Settore MED/13 - Endocrinologia, Endocrinology, Diabetes and Metabolism, Endocrinology, Female health, Energy metabolism, medicine.medical_specialty, medicine, Fertility, media_common.quotation_subject, media_common, business.industry, business, Disease prevention, Hormone replacement, Internal medicine, Physiology, Control female
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
,
EC| WAYS
Project
WAYS
Role of Liver Estrogen Receptor in female Energy Metabolism, Reproduction and Aging: What About Your Liver Sexual Functions?
  • Funder: European Commission (EC)
  • Project Code: 322977
  • Funding stream: FP7 | SP2 | ERC
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