publication . Other literature type . Article . 2011

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

Name: SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Keywords: Article

Panchali Goswami; Ivan Dikic; Ivan Dikic; Ariadne Androulidaki; Janoš Terzić; Katrin Rittinger; Liliana Schaefer; John P. Sundberg; Boris Macek; Tomoko Nakagawa; ...

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Open Access

Published: 30 Mar 2011

Publisher: Springer Science and Business Media LLC

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Abstract

SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system disorders and multi-organ inflammation. Here we report that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPIN causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIN-deficient mice. Upon binding to the LUBAC subunit HOIP (also known as RNF31), SHARPIN stimulates the formation of linear ubiquitin chains in vitro and in vivo. Coexpression of SHARPIN and HOIP...

Persistent Identifiers

doi: 10.1038/nature09814

pmid: 21455181

pmc: PMC3085511

Subjects

free text keywords: Article, Ubiquitin ligase, biology.protein, biology, IKBKG, Cell biology, NFKB1, NF-κB, chemistry.chemical_compound, chemistry, Ubiquitin, Caspase 8, FADD, Ubiquitin ligase complex

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