publication . Article . 2007

Genetic variation in a human odorant receptor alters odour perception

Keller, Andreas; Zhuang, Hanyi; Chi, Qiuyi; Vosshall, Leslie B.; Matsunami, Hiroaki;
Open Access
  • Published: 16 Sep 2007
Abstract
Human olfactory perception differs enormously between individuals, with large reported perceptual variations in the intensity and pleasantness of a given odour. Androstenone (5α-androst-16-en-3-one), an odorous steroid derived from testosterone, is variously perceived by different individuals as offensive ("sweaty, urinous"), pleasant ("sweet, floral"), or odourless 1-3. Up to 30% of humans have reduced sensitivity to androstenone, with 6% fitting the criteria of specific anosmia or "odour blindness" to androstenone, which may be a genetically determined trait 1,3,4. The mechanistic basis of this phenomenon is unknown, but it has been hypothesized that genetic v...
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Medical Subject Headings: psychological phenomena and processes
free text keywords: Multidisciplinary, Androstenone, chemistry.chemical_compound, chemistry, Single-nucleotide polymorphism, Odorant Receptor, Biology, Perception, media_common.quotation_subject, media_common, Androstadienone, Receptor, Odour perception, Genetic variation, Genetics
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