publication . Article . 2021

Syntenin-knock out reduces exosome turnover and viral transduction

Kashyap, Rudra; Balzano, Marielle; Lechat, Benoit; Lambaerts, Kathleen; Egea-Jimenez, Antonio Luis; Lembo, Frédérique; Fares, Joanna; Meeussen, Sofie; Kügler, Sebastian; Roebroek, Anton; ...
Open Access English
  • Published: 01 Dec 2021
  • Publisher: NATURE RESEARCH
Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of intraluminal vesicles that compose the source of a major class of exosomes. Syntenin, however, can also support the recycling of these same components to the cell surface. Here, by studying mice and cells with syntenin-knock out, we identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges. This study significantly ...
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free text keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, [SDV]Life Sciences [q-bio], Multidisciplinary, Article, Extracellular signalling molecules, Glycobiology, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q
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