Actions
  • shareshare
  • link
  • cite
  • add
add
auto_awesome_motion View all 6 versions
Publication . Article . 2019

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

Kokurewicz, K.; Brunetti, E.; Welsh, G. H.; Wiggins, S. M.; Boyd, M.; Sorensen, A.; Chalmers, A. J.; +4 Authors
Open Access   English  
Published: 01 Jul 2019 Journal: Scientific Reports, volume 9, issue 1, pages 1-10 (issn: 2045-2322, Copyright policy )
Publisher: Nature Publishing Group
Country: United Kingdom
Abstract
Abstract The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.
Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Medicine lcsh:R lcsh:Science lcsh:Q

arXiv: Physics::Medical Physics Quantitative Biology::Tissues and Organs Physics::Accelerator Physics

Microsoft Academic Graph classification: Monte Carlo method Imaging phantom Electron Optics business.industry business Relativistic quantum chemistry Dosimetry Scattering Irradiation Materials science Collimated light

Subjects

Article, Cancer imaging, Radiotherapy, Multidisciplinary

39 references, page 1 of 4

Fraass, BA. The development of conformal radiation-therapy. Med Phys. 1995; 22: 1911-1921 [OpenAIRE] [PubMed] [DOI]

Jaworski, C, Mariani, JA, Wheeler, G, Kaye, DM. Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 2013; 61: 2319-2328 [OpenAIRE] [PubMed] [DOI]

Murray, LJ. Radiation-induced second primary cancer risks from modern external beam radiotherapy for early prostate cancer: impact of stereotactic ablative radiotherapy (SABR), volumetric modulated arc therapy (VMAT) and flattening filter free (FFF) radiotherapy. Phys Med Biol. 2015; 60: 1237-1257 [OpenAIRE] [PubMed] [DOI]

Perez, CA. 3-Dimensional treatment planning and conformal radiation-therapy - preliminary evaluation. Radiother Oncol. 1995; 36: 32-43 [PubMed] [DOI]

Teh, BS, Woo, SY, Butler, EB. Intensity modulated radiation therapy (IMRT): A new promising technology in radiation oncology. The Oncologist. 1999; 4: 433-442 [PubMed]

Otto, K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008; 35: 310-317 [OpenAIRE] [PubMed] [DOI]

Ammar, A. Lars Leksell’s vision - radiosurgery. Act Neur S. 1994; 62: 1-4 [OpenAIRE] [DOI]

Bragg, WH, Kleeman, R. On the alpha particles of radium and their loss of range in passing through various atoms and molecules. Philos Mag. 1905; 10: 600-602 [OpenAIRE] [DOI]

Durante, M, Paganetti, H. Nuclear physics in particle therapy: a review. Rep Prog Phys. 2016; 79: 96702-96761 [OpenAIRE] [DOI]

Palma, B. Evaluation of the performance of very high-energy electron (VHEE) beams in radiotherapy: Five clinical cases. Med Phys. 2015; 42: 3568-3568 [OpenAIRE] [DOI]

Funded byView all
EC| LASERLAB-EUROPE
Project
LASERLAB-EUROPE
The Integrated Initiative of European Laser Research Infrastructures
  • Funder: European Commission (EC)
  • Project Code: 654148
  • Funding stream: H2020 | RIA
Validated by funder
,
EC| EuPRAXIA
Project
EuPRAXIA
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA)
  • Funder: European Commission (EC)
  • Project Code: 653782
  • Funding stream: H2020 | RIA
,
UKRI| Lab in a bubble
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: EP/N028694/1
  • Funding stream: EPSRC
,
EC| EUCARD-2
Project
EUCARD-2
Enhanced European Coordination for Accelerator Research & Development
  • Funder: European Commission (EC)
  • Project Code: 312453
  • Funding stream: FP7 | SP4 | INFRA