publication . Article . Other literature type . 2019

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

K. Kokurewicz; Enrico Brunetti; Gregor H. Welsh; S. M. Wiggins; Marie Boyd; Annette Sorensen; Anthony J. Chalmers; Giuseppe Schettino; A. Subiel; Colleen DesRosiers; ...
Open Access English
  • Published: 25 Jul 2019 Journal: Scientific Reports, volume 9, issue 1 (eissn: 2045-2322, Copyright policy)
  • Publisher: Nature Publishing Group
  • Country: United Kingdom
Abstract
Abstract The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a col...
Persistent Identifiers
Subjects
arXiv: Physics::Medical PhysicsQuantitative Biology::Tissues and OrgansPhysics::Accelerator Physics
free text keywords: Multidisciplinary, QC, Article, Cancer imaging, Radiotherapy, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q, Optics, business.industry, business, Monte Carlo method, Beam (structure), Electron, Scattering, Dosimetry, Irradiation, Materials science, Imaging phantom, Collimated light
Funded by
RCUK| Lab in a bubble
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/N028694/1
  • Funding stream: EPSRC
,
EC| EuPRAXIA
Project
EuPRAXIA
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA)
  • Funder: European Commission (EC)
  • Project Code: 653782
  • Funding stream: H2020 | RIA
,
EC| EUCARD-2
Project
EUCARD-2
Enhanced European Coordination for Accelerator Research & Development
  • Funder: European Commission (EC)
  • Project Code: 312453
  • Funding stream: FP7 | SP4 | INFRA
,
RCUK| CRITICAL MASS: Collective radiation-beam-plasma interactions at high intensities
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/J018171/1
  • Funding stream: EPSRC
,
EC| ARIES
Project
ARIES
Accelerator Research and Innovation for European Science and Society
  • Funder: European Commission (EC)
  • Project Code: 730871
  • Funding stream: H2020 | RIA
39 references, page 1 of 3

Fraass, BA. The development of conformal radiation-therapy. Med Phys. 1995; 22: 1911-1921 [OpenAIRE] [PubMed] [DOI]

Jaworski, C, Mariani, JA, Wheeler, G, Kaye, DM. Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 2013; 61: 2319-2328 [OpenAIRE] [PubMed] [DOI]

Murray, LJ. Radiation-induced second primary cancer risks from modern external beam radiotherapy for early prostate cancer: impact of stereotactic ablative radiotherapy (SABR), volumetric modulated arc therapy (VMAT) and flattening filter free (FFF) radiotherapy. Phys Med Biol. 2015; 60: 1237-1257 [OpenAIRE] [PubMed] [DOI]

Perez, CA. 3-Dimensional treatment planning and conformal radiation-therapy - preliminary evaluation. Radiother Oncol. 1995; 36: 32-43 [PubMed] [DOI]

Teh, BS, Woo, SY, Butler, EB. Intensity modulated radiation therapy (IMRT): A new promising technology in radiation oncology. The Oncologist. 1999; 4: 433-442 [PubMed]

Otto, K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008; 35: 310-317 [OpenAIRE] [PubMed] [DOI]

Ammar, A. Lars Leksell’s vision - radiosurgery. Act Neur S. 1994; 62: 1-4 [DOI]

Bragg, WH, Kleeman, R. On the alpha particles of radium and their loss of range in passing through various atoms and molecules. Philos Mag. 1905; 10: 600-602 [OpenAIRE] [DOI]

Durante, M, Paganetti, H. Nuclear physics in particle therapy: a review. Rep Prog Phys. 2016; 79: 96702-96761 [OpenAIRE] [DOI]

Palma, B. Evaluation of the performance of very high-energy electron (VHEE) beams in radiotherapy: Five clinical cases. Med Phys. 2015; 42: 3568-3568 [OpenAIRE] [DOI]

Papiez, L, DesRosiers, C, Moskvin, V. Very high energy electrons (50–250 MeV) and radiation therapy. Technol. Cancer Res T. 2002; 1: 105-110 [OpenAIRE] [DOI]

DesRosiers, C, Moskvin, V, Bielajew, AF, Papiez, L. 150–250 MeV electron beams in radiation therapy. Physics in Medicine and Biology. 2000; 45: 1781-1805 [OpenAIRE] [PubMed] [DOI]

Palma, B. Assessment of the quality of very high-energy electron radiotherapy planning. Radiother Oncol. 2016; 119: 154-158 [OpenAIRE] [PubMed] [DOI]

Calvo, FA. Intraoperative irradiation: precision medicine for quality cancer control promotion. Radiation Oncology (London, England). 2017; 12: 36 [OpenAIRE] [DOI]

Yeboah, C, Sandison, GA, Moskvin, V. Optimization of intensity-modulated very high energy (50–250 MeV) electron therapy. Physics in Medicine and Biology. 2002; 47: 1285-1301 [OpenAIRE] [PubMed] [DOI]

39 references, page 1 of 3
Abstract
Abstract The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a col...
Persistent Identifiers
Subjects
arXiv: Physics::Medical PhysicsQuantitative Biology::Tissues and OrgansPhysics::Accelerator Physics
free text keywords: Multidisciplinary, QC, Article, Cancer imaging, Radiotherapy, lcsh:Medicine, lcsh:R, lcsh:Science, lcsh:Q, Optics, business.industry, business, Monte Carlo method, Beam (structure), Electron, Scattering, Dosimetry, Irradiation, Materials science, Imaging phantom, Collimated light
Funded by
RCUK| Lab in a bubble
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/N028694/1
  • Funding stream: EPSRC
,
EC| EuPRAXIA
Project
EuPRAXIA
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA)
  • Funder: European Commission (EC)
  • Project Code: 653782
  • Funding stream: H2020 | RIA
,
EC| EUCARD-2
Project
EUCARD-2
Enhanced European Coordination for Accelerator Research & Development
  • Funder: European Commission (EC)
  • Project Code: 312453
  • Funding stream: FP7 | SP4 | INFRA
,
RCUK| CRITICAL MASS: Collective radiation-beam-plasma interactions at high intensities
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/J018171/1
  • Funding stream: EPSRC
,
EC| ARIES
Project
ARIES
Accelerator Research and Innovation for European Science and Society
  • Funder: European Commission (EC)
  • Project Code: 730871
  • Funding stream: H2020 | RIA
39 references, page 1 of 3

Fraass, BA. The development of conformal radiation-therapy. Med Phys. 1995; 22: 1911-1921 [OpenAIRE] [PubMed] [DOI]

Jaworski, C, Mariani, JA, Wheeler, G, Kaye, DM. Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 2013; 61: 2319-2328 [OpenAIRE] [PubMed] [DOI]

Murray, LJ. Radiation-induced second primary cancer risks from modern external beam radiotherapy for early prostate cancer: impact of stereotactic ablative radiotherapy (SABR), volumetric modulated arc therapy (VMAT) and flattening filter free (FFF) radiotherapy. Phys Med Biol. 2015; 60: 1237-1257 [OpenAIRE] [PubMed] [DOI]

Perez, CA. 3-Dimensional treatment planning and conformal radiation-therapy - preliminary evaluation. Radiother Oncol. 1995; 36: 32-43 [PubMed] [DOI]

Teh, BS, Woo, SY, Butler, EB. Intensity modulated radiation therapy (IMRT): A new promising technology in radiation oncology. The Oncologist. 1999; 4: 433-442 [PubMed]

Otto, K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008; 35: 310-317 [OpenAIRE] [PubMed] [DOI]

Ammar, A. Lars Leksell’s vision - radiosurgery. Act Neur S. 1994; 62: 1-4 [DOI]

Bragg, WH, Kleeman, R. On the alpha particles of radium and their loss of range in passing through various atoms and molecules. Philos Mag. 1905; 10: 600-602 [OpenAIRE] [DOI]

Durante, M, Paganetti, H. Nuclear physics in particle therapy: a review. Rep Prog Phys. 2016; 79: 96702-96761 [OpenAIRE] [DOI]

Palma, B. Evaluation of the performance of very high-energy electron (VHEE) beams in radiotherapy: Five clinical cases. Med Phys. 2015; 42: 3568-3568 [OpenAIRE] [DOI]

Papiez, L, DesRosiers, C, Moskvin, V. Very high energy electrons (50–250 MeV) and radiation therapy. Technol. Cancer Res T. 2002; 1: 105-110 [OpenAIRE] [DOI]

DesRosiers, C, Moskvin, V, Bielajew, AF, Papiez, L. 150–250 MeV electron beams in radiation therapy. Physics in Medicine and Biology. 2000; 45: 1781-1805 [OpenAIRE] [PubMed] [DOI]

Palma, B. Assessment of the quality of very high-energy electron radiotherapy planning. Radiother Oncol. 2016; 119: 154-158 [OpenAIRE] [PubMed] [DOI]

Calvo, FA. Intraoperative irradiation: precision medicine for quality cancer control promotion. Radiation Oncology (London, England). 2017; 12: 36 [OpenAIRE] [DOI]

Yeboah, C, Sandison, GA, Moskvin, V. Optimization of intensity-modulated very high energy (50–250 MeV) electron therapy. Physics in Medicine and Biology. 2002; 47: 1285-1301 [OpenAIRE] [PubMed] [DOI]

39 references, page 1 of 3
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