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Publication . Article . 2019

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

Kokurewicz, K.; Brunetti, E.; Welsh, G. H.; Wiggins, S. M.; Boyd, M.; Sorensen, A.; Chalmers, A. J.; +4 Authors
Open Access   English  
Published: 01 Jul 2019 Journal: Scientific Reports, volume 9, issue 1, pages 1-10 (issn: 2045-2322, Copyright policy )
Publisher: Nature Publishing Group
Country: United Kingdom
Abstract The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.
Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Medicine lcsh:R lcsh:Science lcsh:Q

arXiv: Physics::Medical Physics Quantitative Biology::Tissues and Organs Physics::Accelerator Physics

Microsoft Academic Graph classification: Monte Carlo method Imaging phantom Electron Optics business.industry business Relativistic quantum chemistry Dosimetry Scattering Irradiation Materials science Collimated light


Article, Cancer imaging, Radiotherapy, Multidisciplinary

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Funded byView all
The Integrated Initiative of European Laser Research Infrastructures
  • Funder: European Commission (EC)
  • Project Code: 654148
  • Funding stream: H2020 | RIA
Validated by funder
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA)
  • Funder: European Commission (EC)
  • Project Code: 653782
  • Funding stream: H2020 | RIA
UKRI| Lab in a bubble
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: EP/N028694/1
  • Funding stream: EPSRC
Enhanced European Coordination for Accelerator Research & Development
  • Funder: European Commission (EC)
  • Project Code: 312453
  • Funding stream: FP7 | SP4 | INFRA