publication . Article . 2020

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

Pauline Maisonnasse; Jeremie Guedj; Vanessa Contreras; Sylvie Behillil; Caroline Solas; Romain Marlin; Thibaut Naninck; Andrés Pizzorno; Julien Lemaitre; Antonio Gonçalves; ...
Open Access English
  • Published: 01 Sep 2020
  • Publisher: HAL CCSD
  • Country: France
International audience; Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs that have demonstrated antiviral efficacy in vitro. Among these candidates, hydroxychloroquine (HCQ) has been given to thousands of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-the virus that causes COVID-19-worldwide but there is no definitive evidence that HCQ is effective for treating COVID-194-7. Here we evaluated the antiviral activity of HCQ both in vit...
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free text keywords: MESH: Animals, MESH: Azithromycin, MESH: Disease Models, Animal, MESH: Female, MESH: In Vitro Techniques, MESH: Humans, MESH: Hydroxychloroquine, MESH: Kinetics, MESH: Macaca fascicularis, MESH: Male, MESH: Pandemics, MESH: Pneumonia, Viral, MESH: Time Factors, MESH: Pre-Exposure Prophylaxis, MESH: Respiratory Mucosa, MESH: Treatment Failure, MESH: Betacoronavirus, MESH: Vero Cells, MESH: Viral Load, MESH: Chlorocebus aethiops, MESH: Coronavirus Infections, MESH: Cytokines, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Multidisciplinary, Azithromycin, medicine.drug, medicine, Hydroxychloroquine, Antiviral drug, medicine.drug_class, Pre-exposure prophylaxis, Vero cell, Virus, Viral load, Immunology, Drug, media_common.quotation_subject, media_common, business.industry, business
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European Virus Archive goes global
  • Funder: European Commission (EC)
  • Project Code: 653316
  • Funding stream: H2020 | RIA
Validated by funder
EC| Fight-nCoV
  • Funder: European Commission (EC)
  • Project Code: 101003555
  • Funding stream: H2020 | RIA
Validated by funder
European Vaccine Research and Development Infrastructure
  • Funder: European Commission (EC)
  • Project Code: 730964
  • Funding stream: H2020 | RIA
European Virus Archive GLOBAL
  • Funder: European Commission (EC)
  • Project Code: 871029
  • Funding stream: H2020 | RIA
Validated by funder
Infrastructure nationale pour la modélisation des maladies infectieuses humaines
  • Funder: French National Research Agency (ANR) (ANR)
  • Project Code: ANR-11-INBS-0008
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