Controlling escape from angiogenesis inhibitors
Copyright policy )Controlling escape from angiogenesis inhibitors
Selective inhibition of vascular endothelial growth factor (VEGF) increases the efficacy of chemotherapy and has beneficial effects on multiple advanced cancers, but response is often limited and the disease eventually progresses. Changes in the tumour microenvironment--hypoxia among them--that result from vascular pruning, suppressed angiogenesis and other consequences of VEGF inhibition can promote escape and tumour progression. New therapeutic approaches that target pathways that are involved in the escape mechanisms add the benefits of blocking tumour progression to those of slowing tumour growth by inhibiting angiogenesis.
- University of California System United States
- UCSF Helen Diller Family Comprehensive Cancer Center United States
- University of California, San Francisco United States
- UNIVERSITY OF CALIFORNIA SAN FRANCISCO
Vascular Endothelial Growth Factor A, Tumor Escape (mesh), Vascular (mesh), Oncology and Carcinogenesis, Cell Hypoxia (mesh), Angiogenesis Inhibitors, 11 Medical and Health Sciences (for), Medical and Health Sciences, 42 Health sciences (for-2020), Vascular, Neoplasms, 616, 617, Tumor Microenvironment, Animals (mesh), Animals, Humans, Oncology & Carcinogenesis, Endothelium, 32 Biomedical and Clinical Sciences (for-2020), Neovascularization, Cancer, Pathologic, Cancer (rcdc), Humans (mesh), Neoplasms (mesh), Biomedical and Clinical Sciences, Neovascularization, Pathologic, Health sciences, Cancer (hrcs-hc), Tumor Microenvironment (mesh), Cell Hypoxia, Pathologic (mesh), 3211 Oncology and Carcinogenesis (for-2020), Angiogenesis Inhibitors (mesh), 32 Biomedical and clinical sciences (for-2020), Oncology & Carcinogenesis (science-metrix), Tumor Escape, Endothelium, Vascular, Vascular Endothelial Growth Factor A (mesh)
Vascular Endothelial Growth Factor A, Tumor Escape (mesh), Vascular (mesh), Oncology and Carcinogenesis, Cell Hypoxia (mesh), Angiogenesis Inhibitors, 11 Medical and Health Sciences (for), Medical and Health Sciences, 42 Health sciences (for-2020), Vascular, Neoplasms, 616, 617, Tumor Microenvironment, Animals (mesh), Animals, Humans, Oncology & Carcinogenesis, Endothelium, 32 Biomedical and Clinical Sciences (for-2020), Neovascularization, Cancer, Pathologic, Cancer (rcdc), Humans (mesh), Neoplasms (mesh), Biomedical and Clinical Sciences, Neovascularization, Pathologic, Health sciences, Cancer (hrcs-hc), Tumor Microenvironment (mesh), Cell Hypoxia, Pathologic (mesh), 3211 Oncology and Carcinogenesis (for-2020), Angiogenesis Inhibitors (mesh), 32 Biomedical and clinical sciences (for-2020), Oncology & Carcinogenesis (science-metrix), Tumor Escape, Endothelium, Vascular, Vascular Endothelial Growth Factor A (mesh)
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