snoRNAs contribute to myeloid leukaemogenesis

descriptionPublicationkeyboard_double_arrow_right Article 29 Jun 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 758-760 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Mona, Khalaj; Christopher Y, Park;

doi: 10.1038/ncb3566

pmid: 28659642

snoRNAs contribute to myeloid leukaemogenesis

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Abstract

The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.

Related Organizations

New York University
United States
Memorial Sloan Kettering Cancer Center
United States
Cornell University
United States

Keywords

Leukemia, Myeloid, Acute, Oncogene Proteins, Fusion, RNA, Ribosomal, Core Binding Factor Alpha 2 Subunit, Humans, RNA, Small Nucleolar, Transcription Factors

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