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Somatic cell nuclear transfer

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2002 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 419, pages 583-587 (issn: 0028-0836, eissn: 1476-4687, Copyright policy )
Authors: Wilmut, I.; Beaujean, Nathalie; de Sousa, P.; Dinnyes, A.; King, T.; Paterson, L.; Wells, D.; +1 Authors

doi: 10.1038/nature01079

pmid: 12374931

Somatic cell nuclear transfer

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

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Keywords

570, Nuclear Transfer Techniques, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.BA] Life Sciences [q-bio]/Animal biology, Swine, [SDV]Life Sciences [q-bio], Cloning, Organism, Embryonic and Fetal Development, Mice, [SDV.BDD] Life Sciences [q-bio]/Development Biology, Animals, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Fetal Death, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, Ploidies, Sheep, [SDV.BA]Life Sciences [q-bio]/Animal biology, Goats, Cell Cycle, Gene Expression Regulation, Developmental, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Cell Differentiation, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, [SDV] Life Sciences [q-bio], Oocytes, Cattle, Forecasting

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 465
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
465
Top 1%
Top 1%
Top 0.1%
Green
bronze
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