A structural motif in the variant surface glycoproteins of Trypanosoma brucei
Copyright policy )A structural motif in the variant surface glycoproteins of Trypanosoma brucei
The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG sequences. Thus antigenic variation in trypanosomes is accomplished by sequence variation, not gross structural alteration; the extensive sequence differences among VSGs may be required for another reason, such as the avoidance of recognition by helper T cells. Additionally, VSG sequences are found to define families, within a VSG superfamily, which have evolved in the trypanosome genome.
- University of Cambridge United Kingdom
- Merck & Co. United States
- Harvard University United States
- Howard Hughes Medical Institute United States
Models, Molecular, Protein Conformation, Molecular Sequence Data, Trypanosoma brucei brucei, Antigenic Variation, X-Ray Diffraction, Animals, Computer Simulation, Amino Acid Sequence, Sequence Alignment, Variant Surface Glycoproteins, Trypanosoma
Models, Molecular, Protein Conformation, Molecular Sequence Data, Trypanosoma brucei brucei, Antigenic Variation, X-Ray Diffraction, Animals, Computer Simulation, Amino Acid Sequence, Sequence Alignment, Variant Surface Glycoproteins, Trypanosoma
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).203 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!