SNARE-mediated membrane fusion

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2001 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Molecular Cell Biology, volume 2, pages 98-106 (issn: 1471-0072, eissn: 1471-0080,

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Authors: Y A, Chen; R H, Scheller;

doi: 10.1038/35052017

pmid: 11252968

SNARE-mediated membrane fusion

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Abstract

SNARE proteins have been proposed to mediate all intracellular membrane fusion events. There are over 30 SNARE family members in mammalian cells and each is found in a distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane transport specificity but the mechanism by which this specificity is achieved remains controversial. Functional studies have provided exciting insights into how SNARE proteins interact with each other to generate the driving force needed to fuse lipid bilayers.

Related Organizations

Stanford University
United States
Howard Hughes Medical Institute
United States

Keywords

Vesicular Transport Proteins, Animals, Membrane Proteins, SNARE Proteins, Lipids, Membrane Fusion

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