The splice of life: Alternative splicing and neurological disease
Copyright policy )The splice of life: Alternative splicing and neurological disease
Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases. Neuron-specific proteins involved in RNA splicing and metabolism are also affected in several neurological disorders. These findings have begun to bridge what we know about the mechanisms regulating neuron-specific splicing and our understanding of neural function and disease.
- University of Adelaide Australia
- Rockefeller University United States
Neurons, Alternative Splicing, RNA Precursors, Animals, Brain, Humans, RNA-Binding Proteins, Nervous System Diseases
Neurons, Alternative Splicing, RNA Precursors, Animals, Brain, Humans, RNA-Binding Proteins, Nervous System Diseases
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