descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1978 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 276, pages 790-795 (issn: 0028-0836, eissn: 1476-4687,

Authors: Seidman, J G; Leder, P;

doi: 10.1038/276790a0

pmid: 103004

The arrangement and rearrangement of antibody genes

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Abstract

Cloned segments of mouse chromosomal DNA provide direct evidence for the somatic rearrangement of kappa variable and constant region genes in antibody producing cells. This rearrangement apparently affects only one member of an allelic pair of light chain genes.

Related Organizations

National Institute of Health
Pakistan
Laboratory of Molecular Genetics
Poland
Jackson Laboratory
United States
National Institutes of Health
United States

Keywords

Base Sequence, Immunoglobulin Variable Region, Immunoglobulins, Nucleic Acid Hybridization, Embryo, Mammalian, Biochemistry, Transplantable Tumors:, Immunoglobulin kappa-Chains, Mice, Myeloma Proteins, Strains:, Metabolism:, Animals, Immunoglobulin Light Chains, Binding Sites, Antibody, Hereditary Factors:, Antibody-Producing Cells, Immunoglobulin Constant Regions, Serology:, Plasmacytoma

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