Carbamylation of Oxytocin and Arginine-Vasopressin
Copyright policy )Carbamylation of Oxytocin and Arginine-Vasopressin
SYNTHETIC analogues of oxytocin and vasopressin in which the terminal amino group is absent or modified exhibit remarkable differences in biological activity. Whereas desamino-oxytocin is highly active1,2, analogues of oxytocin in which the amino group is substituted by acylation or alkylation retain little pharmacological activity3–5, and some act as antagonists4,6. Similarly, 1-desamino-8-lysine-vasopressin has a relatively high pressor potency1 while 1-N-acetyl-8-lysine-vasopressin is inactive7.
- National Institute for Medical Research Tanzania (United Republic of)
- National Institute for Medical Research United Kingdom
Vasopressins, Research, Guinea Pigs, Uterus, Blood Pressure, Arginine, Oxytocin, Rats, Arginine Vasopressin, Breast Feeding, Animals, Humans, Lactation, Urea, Biological Assay, Female, Cyanates
Vasopressins, Research, Guinea Pigs, Uterus, Blood Pressure, Arginine, Oxytocin, Rats, Arginine Vasopressin, Breast Feeding, Animals, Humans, Lactation, Urea, Biological Assay, Female, Cyanates
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