Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
Copyright policy )Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
AbstractObesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. Primary BMSCs isolated from HFD + F mice showed decreased adipocyte and higher osteoblast differentiation with lower senescent phenotype along with decreased osteoclast formation suggesting improved bone marrow microenvironment promoting bone formation in mice. Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases.
- Academy of Sciences Library Czech Republic
- University of Southern Denmark Denmark
- Institute of Physiology Czech Republic
- Charles University Czech Republic
- KU Leuven Belgium
Life Sciences & Biomedicine - Other Topics, DIET-INDUCED OBESITY, QH301-705.5, INHIBITION, Medicine (miscellaneous), Genetics and Molecular Biology, Bone and Bones/metabolism, MASS, bone, Article, Bone and Bones, CONTRIBUTES, Mice, Omega-3/pharmacology, Bone Marrow, TOMOGRAPHY, Fatty Acids, Omega-3, Humans, Animals, Obesity, Biology (General), Biology, Adiposity, mesenchymal stem cells, Bone Marrow/metabolism, Science & Technology, Animal, 31 Biological sciences, Fatty Acids, OSTEOCLASTS, 32 Biomedical and clinical sciences, Multidisciplinary Sciences, N-3 FATTY-ACIDS, MICE, Disease Models, Animal, TISSUE, Disease Models, General Biochemistry, Science & Technology - Other Topics, metabolic bone disease, Obesity/complications, General Agricultural and Biological Sciences, Life Sciences & Biomedicine, STEM-CELLS
Life Sciences & Biomedicine - Other Topics, DIET-INDUCED OBESITY, QH301-705.5, INHIBITION, Medicine (miscellaneous), Genetics and Molecular Biology, Bone and Bones/metabolism, MASS, bone, Article, Bone and Bones, CONTRIBUTES, Mice, Omega-3/pharmacology, Bone Marrow, TOMOGRAPHY, Fatty Acids, Omega-3, Humans, Animals, Obesity, Biology (General), Biology, Adiposity, mesenchymal stem cells, Bone Marrow/metabolism, Science & Technology, Animal, 31 Biological sciences, Fatty Acids, OSTEOCLASTS, 32 Biomedical and clinical sciences, Multidisciplinary Sciences, N-3 FATTY-ACIDS, MICE, Disease Models, Animal, TISSUE, Disease Models, General Biochemistry, Science & Technology - Other Topics, metabolic bone disease, Obesity/complications, General Agricultural and Biological Sciences, Life Sciences & Biomedicine, STEM-CELLS
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!