Role of perlecan in skeletal development and diseases
Copyright policy )Role of perlecan in skeletal development and diseases
Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization. Recent studies with gene knockout mice and human diseases revealed critical in vivo roles of perlecan in cartilage development and neuromuscular junction activity.
- Juntendo University Japan
- National Institute of Health Pakistan
- University of South Florida United States
- Florida Southern College United States
- State University System of Florida United States
Mice, Knockout, Bone Diseases, Developmental, Molecular Structure, Neuromuscular Junction, Osteochondrodysplasias, Mice, Cartilage, Mutation, Animals, Humans, Heparan Sulfate Proteoglycans
Mice, Knockout, Bone Diseases, Developmental, Molecular Structure, Neuromuscular Junction, Osteochondrodysplasias, Mice, Cartilage, Mutation, Animals, Humans, Heparan Sulfate Proteoglycans
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