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Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects

Authors: Li, Wang; Zhou, Juan; Maccaferri, Nicolò; Krahne, Roman; Wang, Kang; Garoli, Denis;

Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects

Abstract

Plasmonics is the discipline that investigates the use of collective oscillations of conductive electrons in metallic nanostructures, called surface plasmons (SPs), to realize a large set of devices to be applied in sensing, nanomedicine, metamaterials, energy harvesting, and many others. During the past decade, several examples of plasmonic platforms have been proposed for single-molecule studies. Among others, plasmonic nanopores, i.e., sub-100 nm apertures connecting two compartments, are finding more and more interest as a specific family of solid-state nanopores with multiple functionalities. While the reader can find exhaustive details on working principles, fabrication, and applications of plasmonic nanopores for biosensing in recent reviews, here we focus on the applications of plasmonic nanopores as a platform for enhanced spectroscopy of single DNA and protein molecules, discussing in detail which limitations must be overcome to enable large scale multiplexing sequencing.

Countries
Italy, Luxembourg, Sweden
Keywords

Nanoteknik, Spectrum Analysis, Review, DNA, Molecules, Analytical Chemistry, Nanopores, Sequence Analysis, Protein, Raman spectroscopy, : Multidisciplinary, general & others [G99] [Physical, chemical, mathematical & earth Sciences], Genetics, Plasmonics, Nano Technology, Amino Acid Sequence, : Multidisciplinaire, général & autres [G99] [Physique, chimie, mathématiques & sciences de la terre]

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
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25
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