Antineoplastic Agents, 88. Pimelea prostrata

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1983 English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 46, pages 563-568 (issn: 0163-3864, eissn: 1520-6025,

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Authors: G R, Pettit; J C, Zou; A, Goswami; G M, Cragg; J M, Schmidt;

doi: 10.1021/np50028a024

pmid: 6631438

Antineoplastic Agents, 88. Pimelea prostrata

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Abstract

The aerial portion of Pimelea prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a source of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin (1) and Pimelea factor P2 (2) were found to strongly inhibit growth (ED50 5 X 10(-3) and 8 X 10(-4) micrograms/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) was also found to inhibit growth (T/C 132 at 20 micrograms/kg) of the PS in vivo system. Detailed 1H-nmr (at 400 MHz) and 13C-nmr studies combined with fast atom bombardment mass spectral evidence were employed to confirm the structural assignments.

Related Organizations

Arizona State University
United States
Biodesign Institute
United States

Keywords

Chemistry, Mice, Magnetic Resonance Spectroscopy, Plants, Medicinal, Chemical Phenomena, Leukemia P388, Animals, Antineoplastic Agents, Phytogenic

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