Effect of Glycyrrhizic Acid on Lappaconitine Phototransformation

descriptionPublicationkeyboard_double_arrow_right Article 08 Sep 2007 English Publisher:American Chemical Society (ACS)Journal:The Journal of Physical Chemistry B, volume 111, pages 11,447-11,452 (issn: 1520-6106, eissn: 1520-5207,

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Authors: Valeria S, Kornievskaya; Alexander I, Kruppa; Nicholas E, Polyakov; Tatyana V, Leshina;

doi: 10.1021/jp0739770

pmid: 17824688

Effect of Glycyrrhizic Acid on Lappaconitine Phototransformation

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Abstract

1H NMR and CIDNP methods were used to demonstrate that triterpene glycoside (glycyrrhizic acid, GA) can substantially change the efficiency and direction of phototransformation of alkaloid lappaconitine (LA) due to both its solubilization in GA micelles and protonation of LA amine nitrogen in water-alcohol solutions. The LA solubilization in the GA micelle suppresses the process of deacylation.

Related Organizations

Institute of Chemical Kinetics and Combustion
Russian Federation

Keywords

Magnetic Resonance Spectroscopy, Photolysis, Molecular Structure, Aconitine, Acylation, Glycyrrhizic Acid, Solutions, Solubility, Protons, Micelles

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