publication . Article . Other literature type . 2019

siRNA Silencing by Chemically Modified Biopolymeric Nanovectors

Miguel A. Valdez; Silvia Barbosa; Sonia Al-Qadi; Pablo Taboada; Raquel Martínez-Gonzalez; Alberto Pardo; Josué Juárez; Eva Villar-Alvarez; Adriana Cambón; Baltazar H. Leal; ...
Open Access
  • Published: 21 Feb 2019 Journal: ACS Omega, volume 4, pages 3,904-3,921 (issn: 2470-1343, eissn: 2470-1343, Copyright policy)
  • Publisher: American Chemical Society (ACS)
  • Country: Spain
Abstract
The ability to specifically silence genes by RNA interference has an enormous potential for treating genetic diseases. However, different drawbacks such as short interfering RNA (siRNA) degradability by serum nucleases and biodistribution issues still need to be overcome to develop suitable delivery vehicles that have been proven essential in carrying siRNA to its target. Chitosan is an attractive biomaterial to construct gene nanocarriers as it is safe, cheap, and amenable to chemical modifications. However, the transfection efficiency of nanovectors based on unmodified chitosan has revealed to be relatively low and dependent on different factors such as the bi...
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Subjects
free text keywords: Genetics, Fluorescence, Hydrophobicity, Gene delivery, Biopolymers, RNA interference, Sirna silencing, Chemistry, Cell biology, Gene, Small interfering RNA, lcsh:Chemistry, lcsh:QD1-999
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