publication . Article . Conference object . 2019

Functional carbon quantum dots as medical countermeasures to human coronavirus (HCoV)

Łoczechin, Aleksandra; Séron, Karin; Barras, Alexandre; Giovanelli, Emerson; Belouzard, Sandrine; Chen, Yen-Ting; Metzler-Nolte, Nils; Boukherroub, Rabah; Dubuisson, Jean; Szunerits, Sabine;
Open Access English
  • Published: 20 Nov 2019
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anti-coronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived by hydrothermal carbonization from ethylenediamine/citric acid as carbon precursors and post-modified with boronic acid ligands. These nanostructures showed a concentration dependent virus inactivation with an estimate...
Persistent Identifiers
Subjects
Medical Subject Headings: virus diseases
free text keywords: human coronavirus (HCoV), carbon quantum dots (CQDs), antiviral therapy, boronic acid, multivalent interactions, [SDV]Life Sciences [q-bio], human coronavirus (HCoV);carbon quantum dots (CQDs);antiviral therapy;boronic acid;multivalent interactions, General Materials Science, Highly pathogenic, Carbon quantum dots, Human coronavirus, Antiviral therapy, Materials science, Virology
Communities
Communities with gateway
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Funded by
EC| PANG
Project
PANG
Pathogen and Graphene
  • Funder: European Commission (EC)
  • Project Code: 690836
  • Funding stream: H2020 | MSCA-RISE
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