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Publication . Article . Preprint . 2019

Real-Time Monitoring of Cellular Cultures with Electrolyte-Gated Carbon Nanotube Transistors

Francesca Scuratti; Giorgio E. Bonacchini; Caterina Bossio; Jorge Mario Salazar-Rios; Wytse Talsma; Maria Antonietta Loi; Maria Rosa Antognazza; +1 Authors
Open Access
English
Published: 16 Oct 2019 Journal: ACS Applied Materials & Interfaces, volume 11, issue 41, pages 37,966-37,972 (issn: 1944-8244, eissn: 1944-8252, Copyright policy )
Country: Netherlands
Abstract
Cell-based biosensors constitute a fundamental tool in biotechnology, and their relevance has greatly increased in recent years as a result of a surging demand for reduced animal testing and for high-throughput and cost-effective in vitro screening platforms dedicated to environmental and biomedical diagnostics, drug development, and toxicology. In this context, electrochemical/electronic cell-based biosensors represent a promising class of devices that enable long-term and real-time monitoring of cell physiology in a noninvasive and label-free fashion, with a remarkable potential for process automation and parallelization. Common limitations of this class of devices at large include the need for substrate surface modification strategies to ensure cell adhesion and immobilization, limited compatibility with complementary optical cell-probing techniques, and the need for frequency-dependent measurements, which rely on elaborated equivalent electrical circuit models for data analysis and interpretation. We hereby demonstrate the monitoring of cell adhesion and detachment through the time-dependent variations in the quasi-static characteristic current curves of a highly stable electrolyte-gated transistor, based on an optically transparent network of printable polymer-wrapped semiconducting carbon-nanotubes.
Subjects by Vocabulary

Microsoft Academic Graph classification: Electrical network law.invention law Process automation system Context (language use) Carbon nanotube field-effect transistor Field-effect transistor Biosensor Bioelectronics Transistor Nanotechnology Materials science

Subjects

General Materials Science, Instrumentation and Detectors (physics.ins-det), Biological Physics (physics.bio-ph), Quantitative Methods (q-bio.QM), FOS: Physical sciences, FOS: Biological sciences, Physics - Instrumentation and Detectors, Physics - Biological Physics, Quantitative Biology - Quantitative Methods, biosensor, cells proliferation, semiconducting carbon nanotubes, bioelectronics, electrolyte gated transistor, FIELD-EFFECT TRANSISTORS, ORGANIC TRANSISTORS, COLORIMETRIC ASSAY, CYTOTOXICITY

Funded by
EC| HEROIC
Project
HEROIC
High-frequency printed and direct-written Organic-hybrid Integrated Circuits
  • Funder: European Commission (EC)
  • Project Code: 638059
  • Funding stream: H2020 | ERC | ERC-STG
Validated by funder
,
EC| LION-HEARTED
Project
LION-HEARTED
Light and Organic Nanotechnology for Cardiovascular Disease
  • Funder: European Commission (EC)
  • Project Code: 828984
  • Funding stream: H2020 | RIA
Validated by funder
,
EC| LINCE
Project
LINCE
Light INduced Cell control by Exogenous organic semiconductors
  • Funder: European Commission (EC)
  • Project Code: 803621
  • Funding stream: H2020 | ERC | ERC-STG
Validated by funder
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NARCIS
Article . 2019
Providers: NARCIS
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