publication . Article . 2018

Halterman Corroles and Their Use as a Probe of the Conformational Dynamics of the Inherently Chiral Copper Corrole Chromophore

Kolle E. Thomas; Laura J. McCormick; Daniel Carrié; Hugo Vazquez-Lima; Gérard Simonneaux; Abhik Ghosh;
Open Access English
  • Published: 02 Apr 2018
  • Publisher: HAL CCSD
Abstract
© 2018 American Chemical Society. Halterman corroles have been synthesized for the first time from pyrrole and Halterman's aldehyde via Gryko's "water-methanol method". These were derivatized to the corresponding copper complexes and subsequently to the β-octabromo complexes. Electronic circular dichroism spectra were recorded for the enantiopure copper complexes, affording the first such measurements for the inherently chiral Cu corrole chromophore. Interestingly, for a given configuration of the Halterman substituents, X-ray crystallographic studies revealed both P and M conformations of the Cu-corrole core, proving that the substituents, even in conjunction w...
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free text keywords: [CHIM.COOR]Chemical Sciences/Coordination chemistry, Physical and Theoretical Chemistry, Inorganic Chemistry, Inorganic & Nuclear Chemistry, Inorganic Chemistry, Chemical Engineering, Other Chemical Sciences, Chiral column chromatography, Steric effects, Enantiomer, Pyrrole, chemistry.chemical_compound, chemistry, Crystallography, Corrole, Enantiopure drug, Chromophore, Chirality (chemistry)
Funded by
EC| EPOS
Project
EPOS
European Plate Observing System
  • Funder: European Commission (EC)
  • Project Code: 262229
  • Funding stream: FP7 | SP4 | INFRA
,
EC| PROMOTE
Project
PROMOTE
The molecular mechanism of the reversible switch between cell proliferation and migration. The regulatory function of the ERK pathway and ERK pathway scaffold RACK1
  • Funder: European Commission (EC)
  • Project Code: 231086
  • Funding stream: FP7 | SP3 | PEOPLE
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EPOSEPOS Projects: EPOS
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