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Publication . Article . 1996

Retroviral integrases and their cousins

Rice, Phoebe; Craigie, Robert; Davies, David R.;
Open Access  
Published: 01 Feb 1996
Publisher: Elsevier BV
Abstract The recently determined structures of the catalytic domains of HIV integrase, avian sarcoma virus integrase and the Mu transposase are strikingly similar to each other and also exhibit significant similarity to several nucleases. All these enzymes cut polynucleotides, leaving 3′OH and 5′PO 4 groups. The integrase and transposase also possess a strand-transfer activity that splices DNA. The structural similarities among members of this superfamily of polynucleotidyl transferases suggest that they share a similar mechanism of catalysis.
Subjects by Vocabulary

Microsoft Academic Graph classification: Polynucleotide Avian sarcoma virus Transposase Genetics Integrases DNA chemistry.chemical_compound chemistry Mu transposase Biology Integrase biology.protein Enzyme chemistry.chemical_classification


Molecular Biology, Structural Biology

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