publication . Article . 2014

On the retention of gene duplicates prone to dominant deleterious mutations

Malaguti, Giulia; Singh, Param Priya; Isambert, Hervé;
Open Access
  • Published: 01 May 2014
  • Publisher: Elsevier BV
Abstract
Recent studies have shown that gene families from different functional categories have been preferentially expanded either by small scale duplication (SSD) or by whole-genome duplication (WGD). In particular, gene families prone to dominant deleterious mutations and implicated in cancers and other genetic diseases in human have been greatly expanded through two rounds of WGD dating back from early vertebrates. Here, we strengthen this intriguing observation, showing that human oncogenes involved in different primary tumors have retained many WGD duplicates compared to other human genes. In order to rationalize this evolutionary outcome, we propose a consistent p...
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free text keywords: Ecology, Evolution, Behavior and Systematics, Population genetics, Mutation, medicine.disease_cause, medicine, Population, education.field_of_study, education, Locus (genetics), Gene family, Human genome, Gene duplication, Negative selection, Evolutionary biology, Biology, Genetics
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