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Mechanisms of Ageing and Development
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Article . 2020
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Article . 2020
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Mechanisms of Ageing and Development
Article . 2020 . Peer-reviewed
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Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Authors: Joana Neves; Pura Muñoz-Cánoves; Pura Muñoz-Cánoves; Pedro Sousa-Victor;

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Abstract

Aging is characterized by the functional and regenerative decline of tissues and organs. This regenerative decline is a consequence of the numerical and functional loss of adult stem cells, which are the corner stone of tissue homeostasis and repair. A palpable example of this decline is provided by skeletal muscle, a specialized tissue composed of postmitotic myofibers that contract to generate force. Skeletal muscle stem cells (satellite cells) are long-lived and support muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss recent advances in the understanding of how satellite cells integrate diverse intrinsic and extrinsic processes to ensure optimal homeostatic function and how this integration is perturbed during aging, causing regenerative failure. With this increased understanding, it is now feasible to design and test interventions that delay satellite cell aging. We discuss the exciting new therapeutic potential of integrating and combining distinct anti-aging strategies for regenerative medicine.

Keywords

Inflammation, Aging, Sarcopenia, Satellite Cells, Skeletal Muscle, Stem Cells, Regenerative Medicine, Epigenesis, Genetic, Myoblasts, Animals, Homeostasis, Humans, Regeneration, Rejuvenation, Muscle, Skeletal, Cellular Senescence, Signal Transduction

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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12
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