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Publication . Article . 2020

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Pedro Sousa-Victor; Joana Neves; Pura Muñoz-Cánoves;
Open Access
Published: 18 Apr 2020 Journal: Mechanisms of Ageing and Development, volume 188, page 111,246 (issn: 0047-6374, Copyright policy )
Publisher: Elsevier BV
Abstract Aging is characterized by the functional and regenerative decline of tissues and organs. This regenerative decline is a consequence of the numerical and functional loss of adult stem cells, which are the corner stone of tissue homeostasis and repair. A palpable example of this decline is provided by skeletal muscle, a specialized tissue composed of postmitotic myofibers that contract to generate force. Skeletal muscle stem cells (satellite cells) are long-lived and support muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss recent advances in the understanding of how satellite cells integrate diverse intrinsic and extrinsic processes to ensure optimal homeostatic function and how this integration is perturbed during aging, causing regenerative failure. With this increased understanding, it is now feasible to design and test interventions that delay satellite cell aging. We discuss the exciting new therapeutic potential of integrating and combining distinct anti-aging strategies for regenerative medicine.
Subjects by Vocabulary

Microsoft Academic Graph classification: Cell aging Rejuvenation Stem cell Regeneration (biology) Regenerative medicine Adult stem cell Neuroscience Biology Tissue homeostasis Skeletal muscle medicine.anatomical_structure medicine


Developmental Biology, Aging

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Tissue regeneration and aging: the decisive quiescent stem-cell state
  • Funder: European Commission (EC)
  • Project Code: 741966
  • Funding stream: H2020 | ERC | ERC-ADG
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Unlocking Precision Gene Therapy
  • Funder: European Commission (EC)
  • Project Code: 825825
  • Funding stream: H2020 | RIA
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Mechanisms of Ageing and Development
License: cc-by
Providers: UnpayWall