publication . Other literature type . Article . 2005

The many faces of the helix-turn-helix domain: Transcription regulation and beyond

Lakshminarayan M. Iyer; L. Aravind; M. Mohan Babu; Santhanam Balaji; Vivek Anantharaman;
Open Access
  • Published: 01 Apr 2005
  • Publisher: Oxford University Press (OUP)
The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. Drawing on the wealth of data that has accumulated over two decades since the discovery of the domain, we present an overview of the natural history of the HTH domain from the viewpoint of structural analysis and comparative genomics. In structural terms, the HTH domains have developed several elaborations on the basic 3-helical core, such as the tetra-helical bundle, the winged-helix and the ribbon-helix–helix typ...
free text keywords: Last universal ancestor, Genomics, Comparative genomics, General transcription factor, Transcription factor, Helix-turn-helix, Gene, Genetics, Biology, Computational biology, Transcription (biology)
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