publication . Article . 2008

Alterations in synaptic transmission and plasticity in area CA1 of adult hippocampus following developmental hypothyroidism

Gilbert, Mary E.; Paczkowski, C.;
Open Access
  • Published: 16 Jan 2008
Transient reductions in thyroid hormone during critical periods of brain development can have devastating and irreversible effects on neurological function. The hippocampus is a brain region sensitive to thyroid hormones and is a necessary substrate for some forms of learning and memory. Subregions within the hippocampus display distinct ontogenetic profiles and have shown differential vulnerability to some indices of thyrotoxic insult. Synaptic function can be readily assessed in the hippocampus, yet little information exists on the consequences of early thyroid hormone insufficiency on the neurophysiological integrity of this structure. Previous work has exami...
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Medical Subject Headings: nervous systemendocrine system
free text keywords: Developmental Biology, Developmental Neuroscience, Endocrinology, medicine.medical_specialty, medicine, Dentate gyrus, Hippocampal formation, Hippocampus, Biology, Synaptic plasticity, Excitatory postsynaptic potential, Long-term potentiation, Internal medicine, Population spike, Neuroscience, Neural facilitation
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